Objective:To investigate the effect of membrane cofactor protein (MCP)on the survival of human cervical ovarian cancer cell. Methods:The expression of MCP mRNA and protein was explored by real-time PCR and Western blot,meanwhile,the effect of MCP on the migration and proliferation of ME180 cell was measured by Transwell and methyl thiazolyl tetrazolium respectively. The augment of human cervical ovarian cancer cells was detected by using MTT method,and the migration of such cells were evaluated by Transwell. Results:The results showed that the expression of MCP significantly increased in human cervical cancer tissue,which contributed to increasing the cells migration and augment the number of ME180 cells. Conclusion:The high expression of MCP in human cervical ovarian cancer cells might be the key machanism of the survival of such cells,and play a vital role in the promotion process.