Objective:To observe the indexes of syndromes of traditional Chinese medicine (TCM) in patients during the perioperative period of cardiopulmonary bypass (CPB)operations,and evaluate the effect of FuXinJian on TCM syndromes in patients with resistance mechanism disorders after CPB operations. In addition,to investigate the etiology and pathogenesis of resistance mechanism disorders after CPB operations,as well as the clinical application of FuXinJian in CPB operations. Methods:A total of 90 patients were divided into 3 groups according to completely randomized design,who needed CPB in open heart valve replacement surgery,as well as qi-deficiency and blood-stasis type or heart-blood stasis type. The 3 groups were the FuXinJian preoperative intervention group(n = 30),the FuXinJian postoperative intervention group(n = 30)and the control group(n = 30). The scores of indexes and the rates of score reduction of TCM symptoms(clinical symptoms)in patients were observed and recorded in 7 days before operations(T1),one day before operations(T2),one day after operations(T3),eight days after operations(T4). Results:The scores of the indexes of TCM symptoms(clinical symptoms) in patients of all of the 3 groups had no significant difference in T1,and the clinical data of the 3 groups had comparability (P > 0.05). Compared with the control group,the scores of the indexes of TCM symptoms decreased significantly in the first group in T2,T3 and T4,as well as the rates of score reduction increased significantly. No significant difference was detected in the scores of the indexes of TCM symptoms and the rates of score reduction between the second group and the control group in T2,T3. The scores of the indexes of TCM symptoms decreased and the rates of score reduction increased significantly in the second group in T4(P < 0.05). Conclusion:FuXinJian can effectively improve TCM syndromes of resistance mechanism disorders in patients after CPB operations.