Objective:To analyze the CT findings of Castleman’s diseases in order to improve diagnostic level. Methods:CT imaging features of 13 patients with Castleman’s disease proved by surgery pathology were retrospectively reviewed. Results:Pathological changes were found in 7 cases in the retroperitoneal zone,3 cases in right cervical part,1 case in right pharyngeal portion,1 in mediastinum and 1 in pelvic cavity. Eight cases were the lesions with local and disseminated distribution and 5 cases were multicentric. Eleven cases were hyaline vascular subtype, 1 case was plasma cell subtype and 1 case was Castleman’s disease with plasmocytoma. Localized Castleman’s disease often showed large homogeneous soft tissue with calcification and cyst formation,and tumor had significant enhancement which was similar to the enhance model of aorta. Multicentric Castleman’s disease showed multiple soft tissue nodules and moderate to significant enhancement. Conclusion:Localized Castleman’s disease of hyaline vascular subtype has some performance characteristics of CT,while multicentric Castleman’s disease has no imaging feature,so the diagnosis of Castleman’s disease depends on pathology.