Objective:To investigate the therapeutic effect of genipin on renal cell carcinoma,and the relationship of UCP2. Methods:Renal carcinoma cells were treated with different concentrations(0,40,80,120 μmol/L)of genipin. Cell growth inhibition and apoptosis were detected by assay of MTT and flow cytometry. Expression of UCP2 was detected by PCR and ELISA. Contents of ROS and Ca2+ were tested by fluorescence probe. Results:Genipin significantly suppressed the growth and promoted apoptosis rate of renal carcinoma cells,statistical significance were found in 80 and 120 μmol/L groups. Expression of UCP2 was significantly increased in 80 and 120 μmol/L groups. Genipin improved contents of ROS and Ca2+,and statistical significance were found in 80 and 120 μmol/L groups also. Conclusion:Genipin can suppress renal carcinoma cells growth,and UCP2 may be involved in its mechanism.