Objective:To evaluate the neuroprotective effect of borneol and its analogues on glutamic acid induced neuron damage. Methods:The lactate dehydrogenase (LDH) was leaked to extracellular space after the neurons were treated with glutamic acid. The neuroprotective effect of the test drugs was evaluated by the enzyme activity of the extracellular LDH. Results:Borneol(1),bornylfromic acid (3),2-bornylethanol (4),2-bornylacetic acid (5),2-carboxymethylisoborneol (6),2,6-diisopropylbenzonic acid(8),2-(2’,6’-diiso-propylphenyl)ethanol (9) and 2-(2’,6’-diisopropylphenyl)acetic acid (10) showed neuroprotective effect,while bornylamine (2) and menthylformic acid (7) exhibited neuron injury. Conclusion:Borneol and most of its analogues showed neuron protective effect in glutamic acid induced LDH releasing model,among which,2,6-diisopropylbenzonic acid (8) showed good neuroprotective effect in the concen-tration of 1 × 10-5~1 × 10-7 mol/L. This deserves further research.