Objective:To explore the effect of high-glucose peritoneal dialysate (HGPDS) and fluvastatin (Flu) on the expression of vascular endothelial growth factor(VEGF) in human peritoneal mesothelial cells(HPMCs). Methods:After incubated in DMEM with 0.01% FBS for 48 h, HPMCs were randomly divided as follows:control group, HGPDS group, HGPDS+Flu group, Flu alone group. The phenotype changes of HPMCs were observed by light microscopy. The mRNA expression of VEGF was observed by RT-PCR. HPMCs were treated for 48 h and the levels of VEGF protein were measured by Western blot. Results:Compared with the normal control group, after incubation with HGPDS for 48 h, the cell morphology was changed from a typical cobblestone-like appearance to fibroblast-like appearance. Flu (1 × 10-6) mol/L could partially improved the cell morphology changed by HGPDS. The mRNA and protein expressions of VEGF increased time dependently in HPMCs treated with HGPDS(P < 0.05), which peaked at 12 h and 48 h, respectively. Flu significantly inhibited the effects of HGPDS on the expression of VEGF in a dose-dependent manner(P < 0.05). Conclusion: Flu could decrease VEGF expression in HPMCs which was induced by HGPDS.