Objective:To analyze trends of the antibacterial drugs used against Acinetobacter baumannii from 2007 to 2010 in 19 general tertiary and secondary hospitals of Nanjing region so as to promote rational use age of medicines. Methods:The use of 7 classes and 15 kinds of antibacterial drugs were calculated and analyzed by the defined daily dose(DDD). The trend of each drug＇s use age was determined with linear regression using SPSS17.0. Results:The comsumptions of carbapenem,fluoroquinolone,piperacillin/tazobactam were increased and cefoperazone/consumption was decreased in general tertiary hospitals. While the comsumptions of carbapenem,tetracycline,cephalosporin,piperacillin/tazobactam,cefoperazone/sulbactam were increased in general secondary hospitals. Total consumption of carbapenem,tetracycline,piperacillin/tazobactam were increased in 19 hospitals. Mean consumption of all antibacterial drugs in every 6 months in general tertiary hospitals was more than these in general secondary hospitals except ciprofloxacin. Conclusion:The use of carbapenem,piperacillin/tazobactam and total drugs rose a significantly in all general hospitals of Nanjing area. Strengthening the infection control and optimizing the use age of drug therapy should be necessary in clinical practice.