Objective:To investigate the clinical value of color doppler ultrasound in evaluation of the effect of neoadjuvant chemotherapy for breast cancer. Methods:Total 65 patients with breast cancers before and after neoadjuvant therapy were examined with color doppler ultrasound. The index of ultrasound was observed,the degree of blood flow and hemodynamics index of the tumor were observed. Results:After neoadjuvant chemotherapy,there were significant differences in decrease of tumor size,volume,morphology irregularity,existence of surrounding halo,distinct boundary,increasing of internal echoes and rear echo. At the same time,the degree of blood flow and hemodynamics index of the tumor were decreased. Conclusion:Color doppler ultrasound provides an effective method in the evaluation of the effect of neoadjuvant chemotherapy in patients with primary breast cancer.