Objective:To study population distribution,ADR level,route of administration and the serious ADR reports of antineoplastic adverse drug reactions,in order to help related population to increase health awareness,pay attention to the prevention of cancer and minimize serious adverse drug reactions. Methods:Downloaded ADR reports occurred and reported in Affiliated Drum Tower Hospital of Nanjing University in 2011 from National Adverse Drug Reaction Monitoring Network database. We performed Excel to statistical analyze the medical records and data by category of age,gender,types of drugs,route of administration and ADR level. Results:Antineoplastic ADR had 422 cases,ranking the first place of all types of drugs. Among 1 503 cases of ADR reported in 2011,the mean age of 357 cases of adverse reactions was 50~59 years old,significantly higher than other age,in which there were 163 male cases and 194 female cases. Of the 357 cases,there were 151 cases of antineoplastic ADR,in which there were 90 male cases and 61 female cases. Of 422 cases of antineoplastic ADR,there were 349 cases (82.70%) in the level of severe or severe new,route of administration was mostly intravenous infusion (385 cases,91.23%). Severe antineoplastic adverse reactions were firstly caused by Oxaliplatin (50 cases). Conclusion:ADR is significantly reduced after the anti-infective standardized management,but is significant increased in the proportion of antineoplastic ADR. Antineoplastic ADR mostly occurred in the 50~59 years old male population. This particular population should pay special attention to cancer prevention and rational use of drugs to minimize the serious adverse reactions.