Objective:To investigate the association of -347G→GA polymorphism located in the CDH1 gene promoter region with the expression of E－cadherin in sporadic colorectal cancer(CRC). Methods:The case－control study was designed,based on the population of colorectal cancer in China and healthy normal controls who have no tumor or inherited disease history. Polymerase chain reaction－restriction fragment length polymorphism(PCR－RFLP) was used to genotype the variant,and immunohistochemical staining was performed to measure the expression of E－cadherin in different allele cases among the CRC patients and normal controls. Results:There was no significant difference in the genotype frequencies of the polymorphism between normal controls and CRC patients(P > 0.05),there was no significant difference in E－cadherin expression for the GA－allele and G－allele in normal controls(P > 0.05),E－cadherin expression was lower for the GA－allele than for the G－allele in CRC patients (P < 0.05),which was no significant difference in normal controls (P > 0.05). Conclusion:The -347G→GA promoter polymorphism of CDH1 gene play no role in the etiology of CRC independently,but may be a prognostic factor during the progression of CRC.