Objective:To investigate the association of plasma high sensitive C－reactive protein(hs－CRP) level and hemorrhagic stroke(HS). Methods:A case－control study(1∶2 matched) was conducted and 149 patients with acute cerebral hemorrhage from a county hospital and 298 age－ and sex－ matched controls from community－based population were selected in 2009. A unified questionnaire was managed to collect demographic information and history of disease. Blood pressure was measured and fasting glucose,plasma lipid and hs－CRP were detected. Cox model regression was applied to evaluate the association of hs－CRP level and hemorrhagic stroke. Results:The level of plasma hs－CRP in HS cases was significantly higher than that of controls (P < 0.001). The association of hs－CRP and HS was statistically significant and OR (95%CI) was 1.386 (1.230~1.563) for per 1 mg/L increasing (P < 0.001) after adjusted for histories of hypertension and diabetes,glucose and lipid. OR (95%CI) of hs－CRP elevation (≥3 mg/L) and HS was 6.599 (3.141~13.867) after adjusted for confounding factors (P < 0.001). Further stratification analysis by sex showed that men and women presented different associations of hs－CRP elevation and HS,and the ORs (95%CI) were 8.675 (3.206~23.469) and 3.836 (1.106~13.308) respectively. Conclusion:Our finding indicated that plasma hs－CRP elevation was significantly associated with increased risk of HS and the association was different between male and female.