Objective:To explore the efficacy and safety of anticoagulant therapy and local thrombolytics in patients with cerebral venous and sinus thrombosis(CVST). Methods:The clinical data of 24 patients with CVST were retrospectively analyzed. These patients were observed after discharge and followed up for 1~3 years. Results:In all the patients included,16 patients only anticoagulated with heparin,8 patients received anticoagulation with heparin and local thrombolytic treatment. At admittion,8 cases showed isolated intracranial hypertension,11 cases with focal deficit,2 cases with encephalopathy and 3 cases with coma. Both the anticoagulation and local thrombolytics were effective. At the end of the follow－up,17 cases (71%) were independent,3 cases (13%) were dependent and 4 cases(17%) died. Concomitant haemorrhageic infarcts related to CVST before treatment were not associated with a poor outcome. Independent predictors of poor outcome were mental disturbance,coma,multiple CVST while predictors of good outcome were thrombosis of single sinus and thrombolytic treatment followed by anticoagulant treatment. Conclusion:In our study,both the heparin therapy and local thrombolysis showed the safety and efficacy in patients with CVST. Local thrombolysis may be a therapeutic option for patients at high risk for a poor outcome despite heparin therapy,possibly in those with intracranial haemorrhages and coma.