The association between TRAF1-C5 gene rs3761847 polymorphism and rheumatoid arthritis in East Asian populations:a meta-analysis
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    Abstract:

    Objective:To explore the association of tumor necrosis factor receptor associted factor 1-complement 5(TRAF1-C5) rs3761847 polymorphism with rheumatoid arthritis (RA) susceptibility in East Asian. Methods:We searched all the publications about the association between TRAF1-C5 polymorphism and RA in East Asian population from PubMed,EMBase,SinoMed,CNKI and Wanfang. Meta-analysis was performed for A allele versus G allele,genotypes AA versus GG,GA versus GG,AA versus GG + GA and GA + AA versus GG using the Stata 10.0 software. OR with the association was obtained from the meta-analysis. Then heterogeneity and stratified analysis were conducted in the study. Results:A total of five eligible studies with 7 438 cases and 5 593 controls were included in this meta-analysis. No significant association was found between TRAF1-C5 polymorphism and RA in East Asian population. However,there is heterogeneity (I2 > 50%),then stratified analysis is used. When analyses were limited to country homogeneous population,significant association was found in Chinese and Japanese population,but not found in South Korea population. Conclusion:This meta-analysis demonstrates significant association between TRAF1-C5 polymorphism and RA in Chinese and Japanese population. More multi-center,large sample,homogeneity case-control studies are still needed to explore the association of TRAF1-C5 polymorphism with RA susceptibility in East Asian.

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惠宇坚,吴东迎,范卫民,胡 军. TRAF1-C5基因rs3761847位点多态性与东亚人群类风湿性关节炎关联性的Meta分析[J].南京医科大学学报(自然科学版英文版),2013,(9):1318-1322.

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  • Received:March 27,2013
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  • Online: September 18,2013
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