Objective:To investigate the application of the Addenbrooke’s cognitive examination-revised(ACE-R) to the assessment of global cognition in Parkinson’s disease(PD). Methods:Twenty-four PD patients were included. Their cognitive functions were assessed according to the ACE-R scales. Results:Compared with 11 cases of abnormal MMSE scores and 13 cases of normal MMSE scores in 24 cases of PD patients,the age was significantly different in 2 groups with MMSE(P < 0.05),but the duration of symptoms,Hoehn-Yahr stage and UPDRS-motor were not significantly different. Compared with 14 cases of abnormal ACE-R scores and 10 cases of normal ACE-R scores in 24 cases of PD patients,the duration of symptoms,Hoehn-Yahr stage and UPDRS-motor were significantly different in 2 groups with ACE-R (P < 0.05),but the age was not significantly different. The scores of five cognitive subdomains in ACE-R(attention and concentration,memory,verbal fluency,language and visuospatial) in 2 groups with ACE-R were significantly different(P < 0.005). Conclusion:The ACE-R has higher sensitivity than the MMSE for cognitive assessment in PD patients. The ACE-R is more suitable than the MMSE as a cognitive screening tool for PD patients.