Objective:Based on identification of anatomic landmarks of lateral ventricles, the study aims to measure the volumes and angles of head,body and tail of lateral ventricles in young,middle-aged and old people. Methods:Sixty healthy adults(divided equally into young group,middle-aged group and the elderly group by age) were scanned with T2-MR to determine the anatomic landmarks of lateral ventricle. Then the volumes,angles and numbers of scanning layers were measured in the three groups. The data were analyzed by one-way ANOVA. A lateral ventricle model was three-dimensional reconstructed. Results:All of the anatomic landmarks of lateral ventricles in subjects were distinguished clearly,such as the corpus callosum,septum pellucidum,fornix,head of caudate nucleus and membrane network bifida. The differences of the bilateral anterior horn,body and posterior horn of lateral ventricle and overall volume between the young group and the elderly group were statistically significant(all P < 0.05). The volumes of lateral ventricle between middle-aged group and the young group had no significant differences except the anterior horn of lateral ventricle(P < 0.05). The differences of the bilateral anterior horn,posterior horn of lateral ventricle and overall volume,left and right angles of anterior horn and width of temporal horn of lateral ventricle between the middle-aged group and the elderly group were significant (all P < 0.05). Conclusion:According to the principles to confirm the anatomic landmarks of the lateral ventricle,the study provides a standardized form for measurements of volume and angle of lateral ventricle,which may be helpful for the diagnosis and research of the pathogenesis.