Objective:To introduce a minimally invasive percutaneous nephroscopic necrosectomy experience for infected necrotizing pancreatitis. Methods:Two patients with serve acute pancreatitis received minimally invasive percutaneous nephroscopic necrosectomy in our hospital during 2012. Before the minimally invasive percutaneous nephroscopic necrosectomy along the drainage sinus tract,the first patient underwent one time of percutaneous catheter drainage,the second patient underwent three times of percutaneous catheter drainage and one time of open debridement. Results:Two patients received one time of percutaneous nephroscopic treatment,symptoms of infection was quickly under control. There were no operative mortality and morbidity. Conclusion:Percutaneous nephroscopic necrosectomy is a minimally invasive,safe and efficient treatment for infected pancreatic necrosis when used in selected patients.