Objective: To investigate the feasibility of BOP [bis-(2-oxopropyl)-N-nitro samine]-induced Syrian hamsters pancreatic adenocarcinoma model,and explore the character of the modeling process. Preliminary analysis of related biology characteristics provides a controllable,dynamic and comprehensive foundation for BOP induced pancreatic animal model. Methods:Seventy-three syrian golden hamsters were treated with carcinogen,N-nitrosobis (2-oxopropyl) amine weekly for 4 weeks (20 mg/kg,subcutaeous injection),and sacrificed at 2-week intervals after 4-week from the last injection. Results:The experimental group pancreatic tumors began to appear after 20 weeks after first injection,different from previous reports,and tumorigenicity was significant higher in 28 weeks after injection,Primary tumor specimen implantation verified tumorigenicity,parts of experimental results were inconsistent with previous reports. Conclusion:BOP can successfully induce Syrian hamsters poorly differentiated pancreatic adenocarcinoma,and the 28th week after first time injection was the optimally time for sample collection. Some experimental results are worthy of further in-depth study.