Objective:To explore inhibition of GLP-1 analogues on prostate cancer cells(LNcap). Methods:LNcap cells were treated with different concentrations(0~100 nmol/L)of exenatide for 24 hours. The Optical Density was measured by CCK-8 analysis .The expression of Bcl-2 and Bax protein were measured by Western blot analysis. Results:The viability of LNcap cells was decreased in a dose-dependent manner after the cells treated with exenatide for 24 hours,as well as the rate of Bcl-2/Bax,and the difference between groups was statistically significant(P < 0.05). Conclusion:Exenatide can induce apoptotic cell death in LNcap cells in a dose-dependent manner。