Objective:To analyze clinical data of gonorrhea treatment with antibiotics in Jiangsu province and provide scientific basis for gonorrhea control strategy. Methods:With cluster sampling and face-to-face interview,195 clinical doctors in 13 STD monitoring spots in Jiangsu were investigated with clinical use of antibiotics for gonorrhea treatment. Logistic multifactor regression model was used for multifactor analysis. Results:Among 195 clinical doctors investigated,56.41% of them applied the combination drug therapy;88 doctors were in accordance with National Guidelines during the therapy,accounting for 80%. The combination of other infections and personal experiences and habits accounted for 18.19% and 1.82%,respectively. Those who take cephalosporins as the first choice accounted for 87.69%. The variantion of hospitals and departments had a big influence on the treatment strategy for gonorrhea(P < 0.05). With multifactor analysis,dermatosis specialized hospitals were likely to use combination drug therapy(P < 0.001),and preferred other cephalosporins antibiotics rather than ceftriaxone sodium for gonorrhea treatment(P < 0.001). Instead of the National Guidelines,dermatologists mostly relied on personal habits and experiences to treat gonorrhea(P < 0.05). Conclusion:It is necessary to strengthen the awareness of gonorrhea treatment standards for clinical doctors,especially for the doctors in dermatosis specialized hospitals. Clinical drug application training should be enhanced to improve the level of diagnosis and treatment of gonorrhea,and to better control the STD/AIDS transmission in Jiangsu province.