Objective:To investigate the expression of FcγRⅡFc fragment of IgG,low affinity IIa,receptor(FcγRⅡ) and vascular endothelial growth factor A(VEGF-A) in colorectal cancer and analyze their association,and consequantly explore the mechanism of FcγRⅡin colorectal cancer. Methods:Expression of FcγRⅡand VEGF-A and their association with clinicopathological features were determined using real time polymerase chain reaction(RT-PCR) in 56 cases of colorectal cancer patients. The distribution of the clinicalpathologic and the expression of VEGF-A and FcγRⅡwere analyzed using Fisher’s exact test and the Chi-squared test. Spearman’s rank correlation was used to analyze the correlation between FcγRⅡand VEGF-A expression. Results:FcγRⅡmRNA expression in colorectal cancer tissues was significantly lower than that in matched adjacent normal tissues. FcγRII mRNA expression was significantly related to the patients’ infiltration depth and clinical stage(P < 0.05). VEGF-A mRNA expression in colorectal cancer tissues was significantly higher than that in matched adjacent normal tissues. VEGF-A mRNA expression was significantly related to the patients’ age,tumor size,infiltration depth and clinical stage(P < 0.05). In colorectal carcinoma, FcγRⅡand VEGF-A mRNA expression was significantly negatively correlated (r = -0.104, P = 0.002). Conclusion:The expression of VEGF-A and FcγRⅡwas associated with the clinical features of colorectal cancer. Expression of FcγRII was negatively correlated with VEGF-A. This study indicates that FcγRⅡand VEGF-A expression is related to the tumor invasion and metastasis. FcγRⅡ may become a new cancer immunotherapy target.