Objective:To investigate the expression pattern and significance of SALL4 gene in CIN and cervical cancer. Methods:The expression of SALL4 mRNA in tissues and plasma of 56 cases of cervical cancer,120 cases of CIN,35 cases of normal cervical or chronic cervicitis(control group) was detected by Real-time PCR. The correlation analysis was conducted to assess the relationship between SALL4 expression in tissues and plasma of cervical cancer group. The levels of SALL4 in plasma were detected by enzyme linked immunosorbent assay. Results:The tissue levels of SALL4 mRNA expression in the the control group,CINⅠ group,CINⅡ~Ⅲ group and cervical cancer group were(4.58 ± 0.64) ×10-4,(6.86 ± 0.72)×10-4,(27.03 ± 2.85)×10-4 and(40.8 ± 5.50)×10-4. The plasma levels of SALL4 mRNA expression were (0.14 ± 0.05)×10-4,(0.16 ± 0.07)×10-4,(0.49 ± 0.08)×10-4 and (2.18 ± 0.22)×10-4. The concentration of SALL4 in plasma were (237 ± 45)-滋g/L,(256 ± 59)-滋g/L,(713 ± 62)-滋g/L and(1 135 ± 107)-滋g/L,respectively. With the progress of cervical disease,the expression of SALL4 was increasing gradually,the expression of SALL4 in cervical cancer group was higher than that in other groups(P < 0.01). A positive correlation between SALL4 expression in tissues and plasma was observed in cervical cancer group(r = 0.684,P < 0.01).Conclusion: SALL4 expression was up-regulated in the CIN and cervical cancer tissues and plasma,and it may be probably associated with the initiation,progression of cervical cancer..