Objective:To evaluate the mechanical properties of longitudinal section of carotid plaque in patients with T2DM,and compare the indexes of velocity,strain and strain rate with normal controls. Methods:One hundred subjects were divided equally into diabetic group and control group according to blood glucose level. Acuson Sequoia C2000(Siemens) was used to collect the image data of carotid plaque. Velocity vector imaging technique was performed to detect the motion information of 5 regions of interest on the surface of carotid plaque,and obtain the positive peak,negative peak and peak difference of velocity,strain and strain rate. Results:All indexes of the diabetic group were smaller than the control group. In the two groups,the indexes of velocity were firstly decreased and then increased. And in the diabetic group,the proximal end of shoulder was greater than the remaining points for strain and strain rate. Conclusion:Velocity vector imaging is an effective technique for evaluating the mechanical properties of carotid plaque in patients with T2DM.