Angiogenesis impact on fracture healing in PTH knockout mice
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    Abstract:

    Objective:To explore whether the lack of endogenous PTH causes angiogenesis weakness by reducing the expression of VEGF during fracture healing and delays fracture healing. Methods:We constructed PTH knockouted mice fracture model,and observed fracture healing from X-ray film and detected bone anabolism and angiogenesis using immunohistochemistry. Results:VEGF expression was decreased in PTHKO mice. Immunohistochemical analysis showed that positive PEGAM was reduced. OCN activity was decreased and fracture healing was delayd. Conclusion:Lack of endogenous PTH may release VEGF by reducing mesenchymal stem cells or osteoblasts,reduce vascular fracture,inhibit osteoblastic activity,surpress endochondral ossification and lead to fracture healing delay eventually.

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周浩,孙鹏,周炜,殷国勇,凡进,李青青. PTH敲除小鼠体内血管形成因素对骨折愈合的影响[J].南京医科大学学报(自然科学版英文版),2014,(4):462-466.

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  • Received:October 11,2013
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  • Online: April 18,2014
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