Objective:To investigate the difference of serum CETP activity between premenopausal and postmenopausal women with type 2 diabetes and its relevant metabolic factors. Methods:Fasting blood samples were collected from 113 subjects hospitalized in Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University from September 2011 to June 2012. All these subjects were female patients with type 2 diabetes before and after menopause. CETP activity and some biochemical markers of the subjects were measured. Results:Serum CETP activity of patients with type 2 diabetes was positively correlated with age,BMI,TG,FBG,HbA1c,and was negatively correlated with HDL-C. There was no obvious correlation between serum CETP activity and SP,BP,TC,LDL-C,Lp (a),fasting insulin levels,HOMA-IR,Cr,Urea,UA,ALT,AST,ALP and TBIL. Serum CETP activity of premenopausal women [(3.55 ± 0.24)-滋g/ml] was lower than that of postmenopausal women [(3.99 ± 0.28)-滋g/ml],and the difference was statistically significant(P < 0.01). Conclusion:CETP activity of premenopausal women is lower than that of postmenopausal women,and CETP activity is closely related with age and HDL-C levels.