Comparison of serum CETP activity between premenopausal and postmenopausal women with type 2 diabetes and its influencing factors
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    Abstract:

    Objective:To investigate the difference of serum CETP activity between premenopausal and postmenopausal women with type 2 diabetes and its relevant metabolic factors. Methods:Fasting blood samples were collected from 113 subjects hospitalized in Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University from September 2011 to June 2012. All these subjects were female patients with type 2 diabetes before and after menopause. CETP activity and some biochemical markers of the subjects were measured. Results:Serum CETP activity of patients with type 2 diabetes was positively correlated with age,BMI,TG,FBG,HbA1c,and was negatively correlated with HDL-C. There was no obvious correlation between serum CETP activity and SP,BP,TC,LDL-C,Lp (a),fasting insulin levels,HOMA-IR,Cr,Urea,UA,ALT,AST,ALP and TBIL. Serum CETP activity of premenopausal women [(3.55 ± 0.24)-滋g/ml] was lower than that of postmenopausal women [(3.99 ± 0.28)-滋g/ml],and the difference was statistically significant(P < 0.01). Conclusion:CETP activity of premenopausal women is lower than that of postmenopausal women,and CETP activity is closely related with age and HDL-C levels.

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朱晓慧,郭雯,付真真,高贝贝,陈晓丽,符金香,周红文.女性2型糖尿病患者绝经前后血清CETP活性的差异及其影响因素[J].南京医科大学学报(自然科学版英文版),2014,(4):482-485.

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  • Received:November 13,2013
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  • Online: April 18,2014
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