Objective:To investigate the association between single nucleotide polymorphisms of IL-13 gene and susceptibility to laryngeal cancer in a Chinese population. Methods:A case-control study included 111 laryngeal squamous cell carcinoma (LSCC) patients and 340 cancer-free controls. Genotyping of the polymorphisms located at the 3’untranslated region (UTR) of IL-13 gene was conducted using MGB TaqMan Probe Assay. Logistic regression model was used to assess the contribution of genetic effects on the development of laryngeal cancer. Results:Individuals with IL-13 rs1295685 TT/CT genotypes had a increased risk of laryngeal cancer (adjusted OR = 2.00,95%CI:1.23~3.27,P = 0.005). Particularly among younger patients (OR = 2.72 and 95%CI:1.40~5.28),smokers (OR = 2.07 and 95%CI:1.19~3.58),drinkers (OR = 1.96 and 95%CI:1.03~3.73) and those without a family history of cancer (OR = 2.01 and 95%CI:1.18~3.41). Furthermore,compared with those,who were both nonsmokers and CC carriers,significantly increased risk was observed in those,who were smokers and TT/CT carriers (OR = 6.48 and 95%CI:2.77~15.14). The similar situation was found in drinkers(OR = 7.35 and 95%CI:3.15~17.12). No significant relationship was observed between rs1295685 polymorphism and progression of laryngeal cancer. Conclusion:The polymorphisms of IL-13 gene may play an important role in the etiology of laryngeal cancer.