Objective:To evaluate the protective effects of dopamine and norepinephrine on the actue lung injury(ALI) in a rabbit model of septic shock. Methods:A cecal ligation and puncture procedure combined with intravenous injection of lipopolysaccharides was used to make a septic shock model. Sixty three rabbits were randomly divided into 5 groups:sham operation group(group A,n =7),septic shock group(group B,n = 14),dopamine treatment group(group C,n = 14),norepinephrine treatment group (group D,n = 14),and dopamine combined with norepinephrine treatment group(group E,n = 14). Seven rabbits from each group were sacrificed 3 and 6 hours after septic shock,the concentration values of surfactant protein A and surfactant protein D(SP-A and SP-D)in plasma were tested by ELISA method and the morphological changes of lung tissue were performed at 3 and 6 h. Results:The concentrations of SP-A and SP-D in each group were significantly increased than those in group A(P < 0.05). No significant differences in the concentration values of SP-A and SP-D in plasma were found between group B and C at 3 and 6 h(P > 0.05);in group D and E,the concentration values of SP-A and SP-D in plasma were significantly lower than those in group B at 3 h and 6 h(P < 0.05). The morphological changes of lung tissue were lessened in group D and E than those in group B and C. Conclusion:The lung tissue was injured severely in septic shock model. Norepinephrine or norepinephrine combined with dopamine can relieve the lesion of lung tissue and play a protective role.