Objective:To observe the prognostic value of NT-proBNP testing in thrombolysis therapy in acute pulmonary thromboembolism. Methods:Sixty-two hemodynamically stable patients with acute pulmonary thromboembolism were randomly divided into thrombolysis therapy[TT(+)] group and non-thrombolysis therapy[TT(-)] group. The clinical aspects,vital sign,prognosis before and after thrombolysis treatment were compared between the two groups. And patients were divided into two groups based on serum NT-proBNP level. Clinical indicators of the two groups were compared. Resules:The difference of heart rate,systolic blood pressure,respiratory rate,D-dimer level,PaO2 level before and after treatment had no significant difference between TT (+) group and TT (-) group. Chest symptoms improvement rate and clinical adverse events rate had no significant difference. In patients with high NT-proBNP level,the improvement of heart rate,systolic blood pressure,respiratory rate,D-dimer level,PaO2 level,and chest symptoms improvement rate,clinical adverse events rate in TT (+) group were significantly better than those of TT (-) group. But in patients with normal NT-proBNP level,the clinical indicators had no significant difference. In patients without thrombolytic therapy,the improvement of heart rate,systolic blood pressure,PaO2 level in NT-proBNP normal group was significantly better than NT-proBNP increase group,while clinical adverse events rate was significantly lower than NT-proBNP increase group. But in patients undergo thrombolytic therapy,the difference between NT-proBNP normal group and NT-proBNP increase group was not significantly. Conclusion:Thrombolytic therapy can improve the prognosis of patients with high NT-proBNP level,but in patients with normal NT-proBNP level,the improvement is not obvious.