Objective:To investigate the serum levels of vascular cell adhesion molecule-1 (VCAM-1),interleukin-8 (IL-8),interleukin-11 (IL-11),interferon-inducible protein-10 (IP-10),macrophage inflammatory protein-1-茁 (MIP-1-茁),the regulated upon activation normal T cell expressed and secreted (RANTES),and angiogenin in patients with coronary heart disease (CHD),then analyze the relationship between the 7 cytokines and the characteristic of coronary artery and explore the possibility to treat them as the new biomarker of CHD. Methods:A total of 216 patients were enrolled in this study. The CHD group consisted of 158 patients who were diagnosed with CHD and the control group consisted of 58 patients with normal coronary artery. Serum levels of the seven cytokines were measured and analyzed. Results:①No significant difference was detected in the levels of IL-8,IP-10,MIP-1-茁 and RANTES between the CHD group and the control group,while the levels of VCAM-1,IL-11 and angiogenin in the CHD group were significantly higher than those in the controls (P < 0.05). ②The differences of the serum levels of VCAM-1 and IL-11 were not significant among the single vessel subgroup,two vessels subgroup and the multiple vessels subgroup (P > 0.05),while the levels of angiogenin in the multiple vessels group were significantly higher than those in the single vessel subgroup and two vessels subgroup (P < 0.05). ③The differences of the serum levels of VCAM-1 and IL-11 were not significant among the subgroups with Gensini severity score > 40,21~40 and < 20,respectively. Serum levels of angiogenin in the subgroup with Gensini severity score > 40 were significantly higher than those in the subgroup with the score between 21 and 40 (P < 0.05),and the levels in the subgroup with the score between 21 and 40 were significantly higher than those in the subgroup with the score < 20 (P < 0.05). ④The level of serum angiogenin was positively related with the Gensini severity score (r = 0.27,P = 0.046). Linear correlation analysis revealed that serum level of angiogenin was not associated with risk factors of CHD (P > 0.05). Conclusion:The expressions of VCAM-1,IL-11 and angiogenin increase in the serum of patients with coronary heart disease. The serum level of angiogenin may be a potential biological indicator to evaluate the degree of coronary artery stenosis.