Objective:To evaluate the relationships between serum high-sensitivity C-reactive protein(hs-CRP),cystatin(CysC),apolipoprotein A(ApoA),lipoprotein a[Lp(a)]and the global registry of acute coronary events(GRACE)scores in patients with non-ST segment elevation acute coronary syndrome(NSTE-ACS). Methods:A total of 155 patients with NSTE-ACS who made a definite diagnosis were selected and divided into the non-ST segment elevation myocardial infarction(NSTE-AMI)group and the unstable angina pectoris(UA) group. After admission,GRACE score was calculated and serum levels of hs-CRP,CysC,ApoA and Lp (a) were examined. Eighty-seven patients without coronary heart disease severed as control group. Results:The levels of serum hs-CRP,CysC,Lp(a) and the GRACE risk scores in NSTE-ACS patients were significantly increased compared with the control group,while the level of serum ApoA was significantly decreased and the differences were statistically significant(P < 0.05). With the increase of GRACE risk level,the levels of serum hs-CRP,CysC and Lp (a) were significantly increased,ApoA were significantly decreased and the differences were statistically significant(P < 0.05). The correlation analysis showed that GRACE scores had a positive correlation with hs-CRP,CysC,Lp(a)(r = 0.424,P < 0.01;r = 0.549,P < 0.01;r =0.134,P < 0.05),and a negative correlation with ApoA(r = -0.167,P < 0.01) in NSTE-ACS patients. Furthermore,the multiple linear regression analysis showed that CysC and hs-CRP had the greatest influence on the GRACE score. Conclusion:The levels of serum hs-CRP,CysC,ApoA and Lp(a) are closely related to coronary heart disease,which may be used as good indicators of extent of coronary atherosclerosis. For the NSTE-ACS patients,higher levels of hs-CRP,CysC,ApoA and Lp (a) indicated a higher GRACE scores. Combination of these indexes may have the important clinical value on early risk stratification,evaluation of prognosis and treatment options.