Objective:To evaluate the long-term strategically prognostic value of optimal timely percutaneous coronary intervention (PCI) after fibrinolysis in treatment of acute myocardial infraction (AMI). Methods:The study analyzed 132 patients,who were suffered with ST-elevation myocardial infraction (STEMI) and treated with different strategies either of optimal timely PCI after fibrinolysis or primary PCI,for the disparity of medical information,including the major adverse cardiac event (MACE),left ventricular ejection fraction (LVEF) and N-terminal pro b-type natriuretic peptide (NT-Pro BNP). Results:Beyond the TIMI angiographic flow before PCI,there were no significant difference in MACE,LVEF and NT-Pro BNP levels between the two groups of patients with different strategic therapies within a six-month period. Conclusion:Contrasted with primary PCI,the strategy of optimal timely PCI after fibrinolysis has equivalent impact on long-term prognosis of patients with STEMI. This strategy is also a reliable and feasible alternative for hospitals which are unable to delivery primary PCI service for STEMI patients promptly at an urgent time.