Objective:To investigate the independent and combined effects of smoking status,overall obesity and abdominal obesity on risk of hypertension. Methods:Participants were recruited under the framework of the community diagnosis investigation from Zhonglou district of Changzhou in 2012. In this investigation,a total of 7 437 subjects aged above 18 years were included in this study. Logistic regression model was performed to analyze WC,BMI and smoking as well as the relationship between their interaction and hypertension. We tested an interaction on an additive scale by using an Excel spreadsheet set up by Andersson to calculate relative excess risk due to interaction(RERI),attributable proportion due to interaction(AP),the synergy index(SI),and then estimate the confidence interval(CI). Results:After adjustment for sex,age,alcohol consumption,family history of high blood pressure,occupation,diet and etc,hypertension OR (95%CI) was 2.75 (2.46~3.12) in overweight or obese subjects,and 2.41 (2.13~2.71) in abdominal obese subjects,compared with normal subjects. OR(95%CI) was 1.37 (1.16~1.63) for smokers compared to never smoking subjects. Compared to never smoking and non-abdominal obese subjects,OR (95%CI) was 3.66 (3.07~4.36) in abdominal obese smokers,2.01 (1.78~2.03) in never smoking and abdominal obese subjects,and 1.47 (1.26~1.71) in non-abdominal obese smokers. RERI was 1.18(0.57~1.79),AP was 0.322 and SI was 1.80(1.35~2.38). Conclusion:Smokers have a significantly higher hypertension risk than never smoking subjects. Moreover,this study further demonstrates an additive interaction of smoking and abdominal obesity on hypertension risk.