Objective:To discuss the influence of pregnancy complications on late onset fetal growth restriction (FGR). Methods:A total of 130 patients with FGR and 130 randomly selected normal pregnant women were collected from Nanjing Maternity and Child Health Care Hospital during 2013. The incidences of hypertensive disorder complicating pregnancy,anemia,gestational thyroid hypofunction,gestational diabetes mellitus (GDM) and intrahepatic cholestasis of pregnancy (ICP) in the two groups were compared. Meanwhile,folates of red blood cell in the two groups were also determined for comparative analysis. According to the different symptomatic treatment and nutrition status in FGR fetuses,130 cases of FGR were divided into two subgroups,48 cases in the no-intervention group and 82 cases in the intervention group. The rate reaching the standard of neonatal body weight,premature birth,fetal distress,and neonatal asphyxia,neonatal pneumonia between the two subgroups was compared. Results:Compared with the control group,the occurrence rates of hypertensive disorder complicating pregnancy,anemia and gestational thyroid hypofunction were significantly higher in the FGR group (P < 0.05). However,the difference in the occurrence rates of GDM and ICP between the two groups was not significant (P > 0.05). The level of red blood cell folate in the FGR group was significantly lower than that in the control group (P < 0.05). The rate reaching the standard of normal neonatal body weight in the intervention group was significantly increased compared to that in the none-intervention group (P < 0.05). The incidences of premature birth,fetal distress,neonatal asphyxia and neonatal pneumonia in the intervention group were also lower than those in the none-intervention group (P < 0.05). Conclusion:Hypertensive disorder complicating pregnancy is the most important factor causing fetal growth restriction. Meanwhile, anemia, lack of folic acid and gestational thyroid hypofunction and some other factors also directly affect the growth and development of the fetus. Interventional treatment can significantly improve pregnancy outcome according to etiology.