Objective:The aim of this study was to compare different treatment methods for ventricular eleatrical storm(VES) during establishment of swine model of acute myocardial infarction (AMI). Methods:Thirty-two swine were divided into four groups. Group A,sham group with 7 swine,saline was given by ear vein;group B,8 swine,amiodarone was given;group C,8 swine,metoprolol was given;group D,9 swine,amiodarone and metoprolol were given simultaneously. After anesthesia,each of those groups were implanted with balloons in the mid-distal left anterior descending artery,by inflating or defating the balloons,ischemic preconditioning was performed 3 or 4 times,then sustained occlusion of LAD for 60 min,at last reperfusion performed for 30 min. Results:There were 3 unexpected deaths in the 4 groups. Various arrhythmias occoured during ischemic preconditioning,sustained occlusion and reperfusion period. Compared with group A,there was a decreasing trend of various arrhythmias in groups B,C and D,but the difference was not significant(P > 0.05). Compared with group A,there was a decreasing trend of VES in groups B and C,but the difference was not significant(P > 0.05),but group D deceased significantly(P = 0.005). Correspondingly,compared with group A,there was a decreasing trend of death due to VES in groups B,C and D,but the difference was not significant(P > 0.05). There were no significant difference of venricular arrhythmias uring ischemic preconditioning,sustained occlusion and reperfusion. Deaths duo to VES were increased during ischemic preconditioning and reperfusion compared with sustained occlusion,but the difference was not significant(P > 0.05). Conclusion:VES and deaths duo to VES are more likely to occur during AMI. Combination of amiodarone and metoprolol can effectively reduce the occurrence of VES are deaths due to VES in the swine model of AMI.