Objective:To explore the correlation and prediction effect of serum cholesterol inflammatory factors on coronary plaque stability. Methods:Total of 107 patients with coronary heart disease were selected randomly in our hospital from July, 2013 to May, 2014,55 cases of stable angina pectoris patients (SAP) were set as the SAP group,52 cases of acute coronary syndrome (ACS)patients were set as the ACS group. Total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),total bilirubin(TBil),high sensitive C reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and other inflammatory factors were detected. Results:TC and LDL-C of the ACS group were(6.38 ± 1.17)mmol/L and(5.63 ± 1.12)mmol/L,respectively, higher than those of the SAP group[(4.51 ± 1.06) mmol/L and(4.42 ± 1.05)mmol/L,respectively],which were higher than those of the control group ,and the differences were significant(P < 0.05). TBil of the ACS group was(6.28 ± 0.74)μmol/L,and SAP was(9.96 ± 1.02)μmol/L,lower than those of the control group, and the differences were significant(P < 0.05). Hs-CRP,IL-6 and TNF-α of the ACS group were(19.06 ± 3.72)mg/L,(57.35 ± 4.14)pg/L and(38.11 ± 2.64)pg/L,higher than those of the SAP group[(11.31 ± 2.15)mg/L,(29.60 ± 3.08)pg/L and(26.82 ± 2.13)pg/L,respectively],and were higher than those of the control group,and the differences were significant(P < 0.05). Conclusion:It is indicated that serum TC,LDL-C,IL-6,TNF-α and Hs-CRP were increased in patients with coronary heart disease,and were correlative with coronary plaque stability.