Objective:To investigate the veriation trend of the prevalence of adenocarcinoma of esophagogastric junction (AEG). Methods:The medical records of 4 685 cases diagnosed with gastric cancer in the First Affiliated Hospital of NJMU between 2001 and 2011 were reviewed and analyzed retrospectively. There were 1 824 cases of AEG and 2 861 non-esophagogastric junction adenocarcinoma (NEGA) among them. The veriation trend of proportion of AEG and early adenocarcinoma of esophagogastric junction (EAEG) as well as the distribution of age and gender were evaluated and the average age and the ratio of male to female were compared between the AEG and NEGA group. Results:The proportion of AEG in gastric cancer had not changed during the past 11 years,however,the proportion of EAEG was significantly higher between 2007 and 2011 than that in the period from 2001 to 2006 (12.23% vs 8.47%,P = 0.013). Compared with the NEGA group,patients in the AEG group had higher mean age [(62.7 ± 9.5)vs (59.1 ± 12.7)years,P < 0.001)]and male to female ratio (1 434∶390 vs 1 990∶871,P < 0.001). Conclusion:The prevalence of AEG in gastric cancer was not significantly increased,whereas the proportion of EAEG over the past 5 years was significantly increased. AEG occurs more often in elderly male patients.