Objective:To investigate the quality of oocyte and embryo developmental potential of poor ovarian responders with ovarian dysfunction,aged,ovulation induction contraindications,leading to repeated implantation failure by a conventional stimulation protocol for IVF/ICSI. Methods:The differences between minimal stimulation and natural cycle were compared in embryo development,embryo implantation,clinical pregnancy and outcomes. Results:A total of 2 565 cycles completed IVF/ICSI-ET treatment during January 2010 to November 2012 which includes 1 752 minimal stimulation cycles and 813 natural cycles. The ratios of normal fertilization rate,cleavage rate and good quality embryos all tend to increase with the increase of cycle number. Conclusion:For patients with aged,ovulation induction contraindications,ovarian dysfunction and patients with previous poor ovarian response or low high-quality embryo rate,mild stimulation or natural cycle might be an optimal choice.