Objective:To explore the underlying molecular mechanisms of exogenous bisphenol A(BPA) regulating MCF-7 breast cancer cell migration. Methods: The migration of MCF-7 breast cancer cells was detected by wound healing assay and transwell assay, and further confirmed by adhesion assay. Furthermore, the migratory ratio of MCF-7 breast cancer cells was analyzed by knockdown of Snail. Results: Exogenous BPA was able to increase the expression of Snail in MCF-7 breast cancer cells and decrease the expression of E-cadherin and thus promote cell migration. Knockdown of Snail was able to retard the MCF-7 breast cancer cell migration. Furthermere,BPA stimulation reduced the adhesion ability of MCF-7 breast cancer cells. Conclusion: We demonstrated that exogenous BPA induced MCF-7 breast cancer cell migration by upregulating Snail protein expression. These findings provide a new clue for better understanding the mechanism of breast carcinoma metastasis.