Objective:To explore the expression of colorectal carcinora metastasis associated genel (MACC) in esophageal squamous call careimma(ESCC),and its relatonship with lymphatic metastasis. Methods:Western-blot assays were performed to detect the expression of MACC1 protein in paired sample tissues from 40 ESCC patients and cell lines. Results:The expression levels of MACC1 protein in KYSE510 and EC109 were 0.413 ± 0.175,0.876 ± 0.202,respectively. There were significant differerces in the two ESCC cell lines (P < 0.05). In paired sample tissues from 40 ESCC cases,the expressions of MACC1 protein in tumor tissue specimens and peri-carcinoma tissues were 0.513 ± 0.228 and 0.248 ± 0.179,respectively. There were significant differences in the two tissues,and MACC1 expression in positive lymph mode metastasis speciemens was higher than in other speciemen(P < 0.05).Conclusion: MACC1 may be closely correlated to the oncogenesis,development and metastasis of ESCC.