Objective:To investigate the relationship between the polymorphisms in XPC(rs2228000,rs2228001,rs2470352),XPD(rs13181),XPG(rs17655)and pathologic characterize as well as risk of bladder cancer. Methods:A case-control study was carried out based on 287 patients with bladder cancer and 282 health controls. The genotype of the polymorphisms of XPC,XPD and XPG was detected by massarray SNP. Logistic regression was applied to assess the association between the polymorphisms and risk and pathologic characterize of bladder cancer. Results:There was a significant difference of genotype distribution of XPC rs2228000 in patients and health controls(χ2 =21.949,P < 0.001),and the CT and TT genotype frequencies in patients were higher than those in health controls (CT vs CC:OR=2.01,95% CI 1.41-2.88;TT vs CC:OR = 3.06,95% CI 1.70-5.49);Moreover,the frequencies of those patients who carried T allele were higher than those in controls (CT/TT vs CC:OR = 2.16,95% CI 1.58-3.11). There were significant differences of the genotype frequencies of rs17655,rs2228000 and rs2228001 among the patients with different tumor differentiation degree (rs17655:χ2 = 10.013,P = 0.040;rs2228000:χ2 = 13.836,P = 0.008;rs2228001:χ2 = 14.315,P = 0.006);moreover,a significant difference of genotype distribution of XPC rs2228000 was observed among those patients who with or without tumor distal metastasis (rs2228000:χ2 = 12.204,P = 0.002). Conclusion:The genotype of XPC rs2228000 was associated with the risk of bladder cancer and tumor differentiation degree and distal metastasis,and those who carried with T allele have higher risk of bladder cancer;Moreover,the genotypes of XPC rs2228001 and XPG rs17655 were associated with tumor differentiation degree.