Objective:To assess the effect of the ratio between contrast medium volume and eGFR for prediction of development of contrast-induced nephropathy (CIN) and the in-hospital prognosis in patients with ST-segment elevation acute myocardial infarction undergoing primary percutaneous coronary intervention (PCI). Method:The study included 215 consecutive patients with STEMI without cardiogenic shock who underwent primary PCI from January 1,2013 to December 4,2013. We calculated their ratio of contrast volume to estimated glomerular filtration rate.ROC methods were used to identify the optimal value of V/eGFR for CIN. The predictive value of V/eGFR was established by Roc curve,and the risk of CIN was assessedusing multivariable logistic regression. Results:Twenty-five(11.6%) patients developed CIN after PCI.V/eGFR is a significantly risk factor of CIN. The ROC curve analysis indicated that a V/eGFR ratio of 2.45 was a fair discriminator for CIN,and a V/eGFR ratio > 2.45 remained significantly associated with CIN (OR 4.15,95%CI 1.19-13.56,P = 0.025). Conclusion:A V/eGFR ratio > 2.45 was a significant predictor of CIN and a poor prognosis in hospital after primary PCI in patients with STEMI.