Objective:To observe analgesis effects and safety of dezocine at a distinct dose on postoperative pain control in patients undergoing abdominal endoscopic surgery. Methods: Sixty patients (ASA physical status: Grade 1~2) were scheduled to undergo abdominal endoscopic surgeries. Those patients were randomly divided into 3 groups with 20 healthy subjects in each group. The fentanyl group (F group): the patients were given fentanyl (1 μg/kg) intravenously 30 min prior to the end of surgical procedure. D1, D2 group: dezocine (100 μg/kg, 200 μg/kg) was substituted for fentanyl, respectively. The visual analogue scale (VAS) for pain at rest at 2, 4, 24 h and in motion was evaluated postoperatively. The time for wake-up from general anesthesia and sedation status of patients after extubation were also recorded. The incidence of postoperative nausea and vomiting (PONV) in 24 h after surgery was recorded. Results: The VAS values at rest at 2, 4, 24 h time points posterior to extubation in F group were higher as compared with D1, D2 group (P < 0.05). The consumption dose of flurbiprofen for rescue of postoperative pain in F Group was higher than the other two groups (P < 0.05). In addition, the VAS values in motion at 4, 24 h in D2 group were significantly reduced in comparison with D1 group (P < 0.05). The Ramsay score in F group was lower than that in D1 and D2 group (P < 0.05). There was no significant difference in time for wake-up from general anesthesia and incidence of PONV among three groups. Conclusion: Dezocine at 100~200 μg/kg was effective in alleviation of postoperative pain and decreased the postoperative consumption of flurbiprofen as a remedy for pain control. Furthermore, dezocine (200 μg/kg) led to the amelioration of pain in motion and was beneficial in early ambulation for patients.