Design and synthesis of twin drug with nNOS-PSD-95 interrupts and gabapentin,pregebalin
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    Abstract:

    Objective:To design and compound of twin drug with nNOS-PSD-95 interrupts and gabapentin,pregebalin,and to find new drugs for the treatment of neuropathic pain. Methods:The nNOS-PSD-95 interrupts and gabapentin,pregebalin were connected to form amide. The analgesic effects of target compounds were evaluated by neuropathic pain model. Results:All target compounds showed different degree analgesic effects in neuropathic pain, the analgesic effect of twin drug of nNOS-PSD-95 interrupts and gabapentin,pregabalin twin drug in neuropathic pain was stronger than that of single target drugs. Conclusion:Twin drug with nNOS-PSD-95 interrupts and gabapentin,pregebalin may get a better analgesic effect than that of single target drugs in neuropathic pain.

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沈 坤,陈 云,匡雨琼,李 飞. nNOS-PSD-95解耦联剂和加巴喷丁、普瑞巴林孪药的设计合成[J].南京医科大学学报(自然科学版英文版),2014,(10):1441-1445.

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  • Received:May 29,2014
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  • Online: November 02,2014
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