Objective:To identify microRNA with different expression and the ease on base mutation based on peripheral blood mononuclear cell from idiopathic membranous nephropathy (IMN) patients. Methods:We used the high-throughput sequencing technology to establish the differently expressed spectrum of microRNA of IMN patients and healthy people (the control group),respectively. We found out the significantly different expression of microRNA. We also analyzed the base edited in the microRNA to find out the microRNA which happened in base mutation, to compare the microRNA between the two groups which in common to evaluate the ease of base mutation. Results:After the creation of microRNA different expression profile,we found out eight microRNAs,which were most significantly different expression,including has-miR-27,has-miR-208b,has-miR-195-3p,has-miR-23b-5p,has-miR-95,has-miR-503,has-miR-449a and has-miR-486-3p. In the common microRNAs between the IMN and the NC groups,there are forty one microRNAs,which had the greater opportunity to have the base edited in the IMN group than in the NC groups. Conclusion:The microRNA expression between the IMN and the NC groups showed significant differences,and the significantly different expression microRNAs were special that could be used as target to further research the pathogenesis of IMN. The microRNAs of IMN patients were more easily to have base edited than that of NC group,and the microRNAs with edited base coulbe possibly related to the pathological mechanism of IMN.