Objective:To investigate the effect of carboxymethytl pachymaram(CMP) on inhibiting apoptosis of human monocyte-derived dendritic cells in vitro. Methods:Human dendritic cells were induced from the peripheral blood monocytes in vitro using recombined human GM-CSF and interleukin (IL)-4,and culture in the presence of CMP at different concentrations (10,50,and 100 mg/L). The percentage of apoptosis and phosphorylated Akt proteins in mature DCs was measured in the presence or absence of CMP by flow cytometry and Western blot,respectively;The expression of CCR7 in mature DCs was measured in the presence or absence of CMP by flow cytometry and Q-PCR,respectively. Results:In CMP-induced DC, the percentage of apoptosis was significantly lower(in the presence of 100mg/L CMP) and the expression of CCR7 and phosphorylated Akt protein significantly higher(in the presence of 50mg/L and 100mg/L CMP) than that of control group,both in a dose-dependent model. Conclusion:CMP can inhibit the apoptosis of human monocyte-derived dendritic cells and its anti-apoptotic mechanism is probably mediated by CCR7 and PI3K/Akt signaling pathway.