Objective:To analyze the CD4+T variation and its impact factors on the HIV/AIDS,who initially had received highly active antiretroviral therapy (HAART) for 1 year in Jiangsu province. Methods:According to the baseline and follow-up data of HIV/AIDS initially receiving HAART with the CD4+T cell count tested in baseline and 1 year after treatment,the deadline of the follow-up was on May 31,2014. Excel database was established and statistical analysis was performed using SPSS 16.0 software. Results:There were 3 290 patients initially receiving HAART with the CD4+ T cell count tested in baseline and 1 year after treatment totally. Eighty-one point four percent of them were from local province; the ratio of male to female was 4.36:1; the average age was 39.7 ± 12.1 years old; 92.3% of the patients were infected with HIV through sexual transmission; the mean CD4+ T cell count of cases was 185.81 cells/μl in baseline,and it increased to 312.20 cells/μl 1 year after treatment and significant differences were found. The age,CD4+T baseline,WHO disease stage,treatment site and regimen influenced the growth value of CD4+ T. Conclusion:HIV/AIDS treatment has a remarkable effect on immunological function rehabilitate for pationts in Jiangsu province. Standardized and early treatment still should be strengthened.