Objective:To study the short-term clinical efficacy and safety in patients undergoing percutaneous coronary rotational atherectomy or percutaneous coronary intervention for severe coronary calcification. Methods: A total of 112 patients with coronary artery intervention treatment that confirmed as severe calcification by coronary angiography were divided into the PTCRA group and the non-PTCRA group. The perioperative complications,mortality and occurrence rates of the major adverse cardiovascular events (MACE) were collected postoperative 9-12 months. Results: There was no statistical difference (P > 0.05) between the two groups on age,sex,hypertension,smoking,diabetes,cholesterol,high-density lipoprotein cholesterol (HDL-c),low density lipoprotein cholesterol (LDL-c),triglycerides,eGFR,heart ejection fraction (EF),and other factors. The mortality and occurrence rates of MACE between the two groups had no statistical difference (P > 0.05):and the PTCRA group had less complications than the non-PTCRA group (P < 0.05). Conclusion: Percutaneous coronary rotational atherectomy with percutaneous coronary intervention can effectively reduce perioperative complications. The treatment for complexity,calcified lesions is safe and effective,and has a good short-term clinical efficacy.