Objective:To compare the expression of serum lipid among ovarian benign epithelial tumor,early and late malignant epithelial tumor,and explore the possible role of blood lipids changes in the occurrence and development of epithelial ovarian tumor. Methods:Total of 200 patients with ovarian epithelial tumor was randomly collected. According to the pathological results after operation,these patients were divided into the benign group with 100 cases,early malignant group and advanced malignant group with 50 cases in each group. Serum lipids were collected,and total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-c),low density lipoprotein cholesterol (LDL-c),lipoprotein (a) were detected. Results:TC and HDL-c levels of malignant group were significantly lower than those in benign group(both P < 0.05). The LP (a) levels of malignant group preferred to be lower than the benign group increased (P=0.061) while the LDL-c showed a decreasing trend than those of the benign group (P=0.061). One-Way ANOVA analysis showed that LP,TC,HDL-c,and LDL-c among the three groups had significant difference(P < 0.05). Furthermore,HDL-c level of benign group was lower than that of the early group significantly (P < 0.001). TC,HDL-c,LDL-c in advanced group decreased significantly than thoses in benign group (P < 0.05),while the LP (a) level of advanced group was higher than that of the benign group (P=0.013). The advanced group and early group had no significant difference on the indicators,and only LP (a) were increased potentially (P=0.052). Logistic regression analysis showed that the level of HDL-c,LDL-c,and LP (a) was related with the development of ovarian tumor. Conclusion:HDL-c,LDL-c,and LP (a) were associated with the degree of development of ovarian epithelial tumors,the more advanced the tumor was,the lower level of HDL-c and LDL-c while the higher level of LP (a) was.