A preliminary study of BRD4 inhibitor JQ1 effects on non-small cell lung cancer cells
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    Abstract:

    Objective:To investigate the effects and mechanism of BRD4 inhibitor JQ1 on the growth of human non-small cell lung cancer (NSCLC)cells including erlotinib resistant cells. Methods:The inhibitory effects of JQ1 on the growth of human NSCLC were observed at different concentrations for 72 hours by sulforhodamine B (SRB)assay. mRNA and protein levels of eIF4E were detected by quantitative real-time PCR assay and Western blot,respectively. Results:JQ1 inhibited the growth of NSCLC cells including erlotinib parental and resistant cells in a dose dependent manner. The mRNA and protein expression levels of eIF4E decreased significantly by JQ1 treatment. Conclusion:JQ1 inhibits the growth of NSCLC cells possibly through downregulating eIF4E expression.

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倪 萍,吴丹丹,翟溯澜,李 萍,邹美娟,李 敏,程志祥,王雪融. BRD4抑制剂JQ1抑制非小细胞肺癌生长的研究[J].南京医科大学学报(自然科学版英文版),2015,(8):1092-1095.

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  • Received:March 13,2015
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  • Online: August 04,2015
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