Objective:To investigate the diagnostic value of real-time shear wave elastography(SWE)technology for the assessment of liver fibrosis in chronic hepatitis B (CHB)patients. Methods:Hepatic elastic modulus of 60 health control people and 68 patients with CHB were measured by SWE,and 68 patients had liver biopsy. The elastic modulus was compared with pathological stages of hepatic fibrosis. Results:The modulus of elasticity had a statistically significant difference in health control people and liver fibrosis patients. The elastic modulus of each pathological stages of hepatic fibrosis included S1 at (7.171 ± 1.819)kpa (n=14),S2 at(10.300 ± 3.121)kPa(n=18),S3 at(15.540 ± 4.341)kPa(n=20),and S4 at(23.919 ± 5.698)kPa(n=16). The elastic modulus of each pathological stages had statistically significant difference (F=50.807,P < 0.001). The elastic modulus was correlated with pathological stages in a correlation coefficient of 0.783 (P < 0.001). The ROC curve was set up by evaluating the pathological stages through elastic modulus. Areas under ROC curve of 0.940 for ≥S2 patients,of 0.947 for ≥S3 patients,of 0.949 for S4 patients. Conclusion:SWE has certain diagnostic efficiency in evaluating liver fibrosis stage in CHB patients.