Objective:To explore the function and regulation mechanism of dopamine(DA)and cocaine-and amphetamine-regulated transcript peptides (CART)in ischemic stroke. Methods:The acute ischemic stroke model in rat was established,accompanied with administration of DA and CART. The neurological deficit scores,infarct volume,and inflammasome activity were detected to clarify the role of DA and CART in acute ischemic. Results:DA and CART reduced neurological deficit scores and infarct volumin in rats with acute ischemic stroke,and inhibited the activation of the inflammasome by reducing Caspase-1 and IL-1β secretion. Moreover,the expression of CART is regulated by DA. Conclusion:Dopamine can reducing inflammasome activity to protect ischemic stroke by regulation of CART.